I got to say I disagree with Nick, not everything has to be hotkeyed. i reckon, per class there is roughly 30-40 abilities and functions that need to be binded, personally I play Hunter, so I have alot of macro's relating to pet abilities. I have my usualy 1 - = bar and then F1 - F12 as well as a WoW gaming mouse with all buttoms bound, I have no problems with this set-up
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